Ciprofloxacin and ofloxacin aqueous humor concentrations after topical administration in dogs undergoing cataract surgery
- 23 May 2005
- journal article
- clinical trial
- Published by Wiley in Veterinary Ophthalmology
- Vol. 8 (3), 181-187
- https://doi.org/10.1111/j.1463-5224.2005.00368.x
Abstract
To determine if preoperative topical administration of ciprofloxacin or ofloxacin results in aqueous humor drug concentrations that exceed the MIC(90) of common ocular contaminants in dogs undergoing cataract surgery. Twelve dogs were treated with topical 0.3% ciprofloxacin and 13 dogs with topical 0.3% ofloxacin once the night before surgery, and then with 1 drop of ciprofloxacin or ofloxacin every 15 min for 2 h immediately before surgery. Aqueous humor samples were taken from each eye immediately before the incision was made and frozen at -70 degrees C. First eye samples (S1) were taken closer to the time of topical treatments than second eye samples (S2). Samples were analyzed by high performance liquid chromatography (HPLC) at the North Carolina State University (NCSU) Clinical Pharmacology laboratory. In ciprofloxacin patients, S1 concentrations were 0.03-0.69 (0.17 median) microg/mL, and S2 concentrations were 0.09-0.95 (0.36 median) microg/mL. Aqueous humor concentrations did not exceed the MIC90 of Streptococcus sp. Few eyes (1/12 OU) exceeded the MIC90 for Staphylococcus sp. or Corynebacterium sp.; moderate numbers (5/12 S1; 8/12 S2) exceeded the MIC90 for E. coli. In ofloxacin patients, S1 concentrations were 0.48-2.81 (1.05 median) microg/mL, and S2 concentrations were 0.45-3.63 (1.30 median) microg/mL. Although few eyes (<or=2/13 OU) exceeded the MIC90 for Streptococcus sp. or Corynebacterium sp., moderate numbers (7/13 S1, 9/13 S2) exceeded the MIC90 for Staphylococcus sp. and most eyes (12/13 OU) exceeded the MIC90 for Bacillus sp. All eyes exceeded the MIC90 for E. coli. Ofloxacin has higher corneal penetration and ability to exceed MIC90 of common ocular contaminants than ciprofloxacin, and would be a more appropriate prophylactic choice for canine cataract patients.Keywords
This publication has 35 references indexed in Scilit:
- Microbial contamination of the anterior chamber during cataract phacoemulsification and intraocular lens implantation in dogsVeterinary Ophthalmology, 2004
- Penetration of topically applied ciprofloxacin and ofloxacin into the aqueous humor and vitreousJournal of Cataract & Refractive Surgery, 2003
- PENETRATION OF TOPICAL AND ORAL CIPROFLOXACIN INTO THE AQUEOUS AND VITREOUS HUMOR IN INFLAMED EYESPublished by Ovid Technologies (Wolters Kluwer Health) ,1999
- Ocular penetration of topical ciprofloxacin and norfloxacin drops and their effect upon eyelid flora.British Journal of Ophthalmology, 1994
- Ofloxacin in Human Serum, Urine, and Tear Film After Topical ApplicationCornea, 1992
- Topical fluoroquinolones: Antimicrobial activity andin vitrocorneal epithelial toxicityCurrent Eye Research, 1991
- OfloxacinDrugs, 1987
- Development of Resistance to OfloxacinDrugs, 1987