Compliance with oral drug therapy in patients with hematologic malignancy.
- 1 September 1987
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 5 (9), 1469-1476
- https://doi.org/10.1200/jco.1987.5.9.1469
Abstract
Compliance with oral self-administered allopurinol (daily medication) and prednisone (intermittent medication) as well as compliance with monthly scheduled clinic appointments, were examined in 108 patients with newly diagnosed hematologic malignancy. Baseline levels of compliance (control group) were compared to results obtained after implementation of three intervention packages, whose aim was to increase compliance. The packages included combinations of education, home psychologic support and restructuring, and training in pill taking. A 24-hour profile of the two drugs and their metabolites was first determined. Serum samples were then obtained monthly over 6 months and analyzed for presence of the drugs. Control patients were fully compliant with allopurinol only 16.8% of the time. This rate increased significantly (44% to 48% of the time) for those who received any one of the intervention programs. With respect to prednisone, control patients were compliant 26.8% of the time, with no real improvement after interventions. Finally, self reports overestimated compliance by a factor of two when compared to drug analysis. The results indicated that full compliance with oral medications was remarkably low among our patients who have treatable and in some cases curable hematologic malignancy. However, compliance can be significantly improved by the use of various intervention packages.This publication has 11 references indexed in Scilit:
- Salvage Chemotherapy with ABVD in MOPP-Resistant Hodgkin's DiseaseAnnals of Internal Medicine, 1982
- Acute toxicity during adjuvant chemotherapy for breast cancer: the National Surgical Adjuvant Breast and Bowel Project (NSABP) experience from 1717 patients receiving single and multiple agents.1981
- Liquid-chromatographic measurement of endogenous and exogenous glucocorticoids in plasma.Clinical Chemistry, 1979
- 5-drug adjuvant chemotherapy for breast cancerCancer, 1979
- Adjuvant chemotherapy for breast carcinoma:Psychosocial implicationsCancer, 1979
- A reliable method for evaluating drug compliance in children with cancerCancer, 1978
- Hydroxyldaunomycin (adriamycin) combination chemotherapy in malignant lymphomaCancer, 1976
- Bleomycin, Adriamycin, Cyclophosphamide, Vincristine, and Prednisone (BACOP) Combination Chemotherapy in the Treatment of Advanced Diffuse Histiocytic LymphomaAnnals of Internal Medicine, 1976
- Advanced Lymphosarcoma: Intensive Cyclical Combination Chemotherapy with Cyclophosphamide, Vincristine, and PrednisoneAnnals of Internal Medicine, 1972
- Combination Chemotherapy in the Treatment of Advanced Hodgkin's DiseaseAnnals of Internal Medicine, 1970