DNA Methylation Decreases in Aging But Not in Immortal Cells
- 3 June 1983
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 220 (4601), 1055-1057
- https://doi.org/10.1126/science.6844925
Abstract
When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.Keywords
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