Motor neurone disease: the nature of the pathogenic mechanism
Open Access
- 1 September 1974
- journal article
- research article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 37 (9), 1036-1046
- https://doi.org/10.1136/jnnp.37.9.1036
Abstract
Evidence is presented which indicates that the initial site of action of the pathogen of motor neurone disease (MND) is the nucleus, and its prime effect is to cause the progressive inhibition of DNA directed mRNA synthesis by the slow condensation of chromatin from a metabolically active diffuse form to an inactive form. The other pathological changes observed follow as part of a nonspecific cell atrophy which leads eventually to dysfunction, death, and disappearance of cells.Keywords
This publication has 3 references indexed in Scilit:
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- Neuronal Enzymatic Failure in Creutzfeldt-Jakob DiseaseArchives of Neurology, 1964
- Differential rate in RNA synthesis between euchromatin and heterochromatinExperimental Cell Research, 1962