Impact of the non‐cellular tumor microenvironment on metastasis: Potential therapeutic and imaging opportunities
- 26 July 2007
- journal article
- review article
- Published by Wiley in Journal of Cellular Physiology
- Vol. 213 (2), 391-402
- https://doi.org/10.1002/jcp.21222
Abstract
Evidence is accumulating that the malignant phenotype of a given tumor is dependent not only on the intrinsic characteristics of tumor cells, but also on the cooperative interactions of non‐neoplastic cells, soluble secreted factors and the non‐cellular solid‐state ECM network that comprise the tumor microenvironment. Given the ability of the tumor microenvironment to regulate the cellular phenotype, recent efforts have focused on understanding the molecular mechanisms by which cells sense, assimilate, interpret, and ultimately respond to their immediate surroundings. Exciting new studies are beginning to unravel the complex interactions between the numerous cell types and regulatory factors within the tumor microenvironment that function cooperatively to control tumor cell invasion and metastasis. Here, we will focus on studies concerning a common theme, which is the central importance of the non‐cellular solid‐state compartment as a master regulator of the malignant phenotype. We will highlight the non‐cellular solid‐state compartment as a relatively untapped source of therapeutic and imaging targets and how cellular interactions with these targets may regulate tumor metastasis. J. Cell. Physiol. 213: 391–402, 2007.Keywords
This publication has 112 references indexed in Scilit:
- Glycated Collagen I (GC) impairs angiogenesis in vitro—A study using an innovative chamber for cell researchDiabetes Research and Clinical Practice, 2007
- Metastasis: recent discoveries and novel treatment strategiesThe Lancet, 2007
- Matrix metalloproteinases and the regulation of tissue remodellingNature Reviews Molecular Cell Biology, 2007
- Identification of novel short peptides derived from the α4, α5, and α6 fibrils of type IV collagen with anti-angiogenic propertiesBiochemical and Biophysical Research Communications, 2007
- Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasisNature, 2006
- Inhibition of Experimental Metastasis by Targeting the HUIV26 Cryptic Epitope in CollagenThe American Journal of Pathology, 2006
- Extracellular Signal-regulated Kinase (ERK)-dependent Gene Expression Contributes to L1 Cell Adhesion Molecule-dependent Motility and InvasionJournal of Biological Chemistry, 2004
- Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generationNature Medicine, 2003
- Tumour-cell invasion and migration: diversity and escape mechanismsNature Reviews Cancer, 2003
- A molecular signature of metastasis in primary solid tumorsNature Genetics, 2002