Deubiquitylating enzymes in neuronal health and disease
Open Access
- 22 January 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell Death & Disease
- Vol. 12 (1), 1-11
- https://doi.org/10.1038/s41419-020-03361-5
Abstract
Ubiquitylation and deubiquitylation play a pivotal role in protein homeostasis (proteostasis). Proteostasis shapes the proteome landscape in the human brain and its impairment is linked to neurodevelopmental and neurodegenerative disorders. Here we discuss the emerging roles of deubiquitylating enzymes in neuronal function and survival. We provide an updated perspective on the genetics, physiology, structure, and function of deubiquitylases in neuronal health and disease.Keywords
Funding Information
- Azrieli Foundation
- Koret Foundation
- Israel Science Foundation (651/16, 651/16)
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