Biochemical studies on adenovirus multiplication. IX. Chemical and base composition analysis of 28 human adenoviruses.
- 1 August 1965
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 54 (2), 547-551
- https://doi.org/10.1073/pnas.54.2.547
Abstract
Human adenovirus types 1 -28 were cultivated, purified in mg amounts, and analyzed for some of their chemical and physical properties. Each adenovirus type appears to contain only protein and a characteristic amount of DNA ranging from 11.6 to 13.5% DNA. The buoyant density and thermal denaturation temperature values of the 28 adenovirus DNA''s were determined and used to calculate their base compositions. The different adenovirus types contain 48-60% G + C (guanosine + cytosine). A correlation was found between base composition and tumorigenicity. Highly oncogenic adenovirus types 12 and 18 possess the lowest G + C content, 48-49%.Keywords
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