Sex and hedgehog: roles of genes in the hedgehog signaling pathway in mammalian sexual differentiation
Open Access
- 22 November 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Chromosome Research
- Vol. 20 (1), 247-258
- https://doi.org/10.1007/s10577-011-9254-z
Abstract
The chromosome status of the mammalian embryo initiates a multistage process of sexual development in which the bipotential reproductive system establishes itself as either male or female. These events are governed by intricate cell–cell and interorgan communication that is regulated by multiple signaling pathways. The hedgehog signaling pathway was originally identified for its key role in the development of Drosophila, but is now recognized as a critical developmental regulator in many species, including humans. In addition to its developmental roles, the hedgehog signaling pathway also modulates adult organ function, and misregulation of this pathway often leads to diseases, such as cancer. The hedgehog signaling pathway acts through its morphogenetic ligands that signal from ligand-producing cells to target cells over a specified distance. The target cells then respond in a graded manner based on the concentration of the ligands that they are exposed to. Through this unique mechanism of action, the hedgehog signaling pathway elicits cell fate determination, epithelial–mesenchymal interactions, and cellular homeostasis. Here, we review current findings on the roles of hedgehog signaling in the sexually dimorphic development of the reproductive organs with an emphasis on mammals and comparative evidence in other species.Keywords
This publication has 76 references indexed in Scilit:
- Eliminating SF-1 (NR5A1) Sumoylation In Vivo Results in Ectopic Hedgehog Signaling and Disruption of Endocrine DevelopmentDevelopmental Cell, 2011
- MPK-1 ERK Controls Membrane Organization in C. elegans Oogenesis via a Sex-Determination ModuleDevelopmental Cell, 2011
- Vascular-mesenchymal cross-talk through Vegf and Pdgf drives organ patterningProceedings of the National Academy of Sciences of the United States of America, 2010
- Sonic hedgehog controls growth of external genitalia by regulating cell cycle kineticsNature Communications, 2010
- Activation of the Hedgehog pathway in the mouse fetal ovary leads to ectopic appearance of fetal Leydig cells and female pseudohermaphroditismDevelopmental Biology, 2009
- Hedgehog does not guide migrating Drosophila germ cellsDevelopmental Biology, 2009
- Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independentDevelopmental Biology, 2009
- Expression of hedgehog signalling components in adult mouse testisDevelopmental Dynamics, 2006
- Male development of chromosomally female mice transgenic for SryNature, 1991
- Mutations affecting segment number and polarity in DrosophilaNature, 1980