Membrane-free microfiltration by asymmetric inertial migration

Abstract

Membrane-free microfiltration by asymmetric inertial migration is studied and evidence of the filtration capability is presented. Centrifugal force induced by flow in spiral channel geometry modifies the lateral symmetry of straight-channel tubular pinch equilibrium resulting in a focused particle band nearer to the inner sidewall. Bifurcated outlets separately collect the concentrated particle band and remaining effluent. The spiral continuous flow filtration relies solely on internal fluidic shear characteristics, eliminating the need for membrane filters or external force fields. This device has the desirable combinations of high throughput and low cost, making it inherently suited for preparative filtration in the range of micro- to macroscale applications.