Potentiation of antidepressant effects by L-triiodothyronine in tricyclic nonresponders
- 1 January 1982
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 139 (1), 34-38
- https://doi.org/10.1176/ajp.139.1.34
Abstract
Six women and 6 men who were treated in double-blind fashion for major depressive illness did not respond to imipramine or amitriptyline, 150-300 mg/day, during periods of 26-112 days. After the addition of 25 .mu.g/day (10 patients) or 50 .mu.g/day (2 patients) of L-triiodothyronine (T3), 9 patients showed statistically significant improvement in depression scores; in 8 patients the response was marked. Improvement generally began within 1-3 days and was noted in all aspects of the depressive syndrome; side efects were minimal. T3 did not change plasma levels of imipramine or desipramine or their ratio but did suppress serum thyroxine.This publication has 1 reference indexed in Scilit:
- Combined Therapy of T3 and Antidepressants in DepressionJournal of International Medical Research, 1979