Localization of the human haptoglobin genes distal to the fragile site at 16q22 using in situ hybridization
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 41 (1), 38-41
- https://doi.org/10.1159/000132193
Abstract
The distamycin A-sensitive fragile site fra(16)(q22) is a precisely localized chromosomal marker. When expressed at metaphase, it visibly separates the chromosome material on either side of the fragile site. Using a cDNA probe encoding both the α and β haptoglobin chains, the haptoglobin loci were found by in situ hybridization to be distal to fra(16)(q22).This publication has 4 references indexed in Scilit:
- HERITABLE FRAGILE SITES ON HUMAN-CHROMOSOMES .11. FACTORS AFFECTING EXPRESSION OF FRAGILE SITES AT 10Q25, 16Q22, AND 17P121984
- High-resolution chromosomal localization of human genes for amylase, proopiomelanocortin, somatostatin, and a DNA fragment (D3S1) by in situ hybridization.Proceedings of the National Academy of Sciences, 1983
- Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridizationProceedings of the National Academy of Sciences of the United States of America, 1982
- Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridizationChromosoma, 1981