Sharing of the Interleukin-2 (IL-2) Receptor γ Chain Between Receptors for IL-2 and IL-4
- 17 December 1993
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 262 (5141), 1874-1877
- https://doi.org/10.1126/science.8266076
Abstract
The gamma chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the gamma chain cross-linked with IL-2, also immunoprecipitated the gamma chain when cross-linked with IL-4. These results suggest that the IL-2 receptor gamma chain is functionally involved in the IL-4 receptor complex.Keywords
This publication has 30 references indexed in Scilit:
- Cloning of the Mouse Interleukin 2 Receptor γ Chain: Demonstration of Functional Differences Between the Mouse and Human ReceptorsBiochemical and Biophysical Research Communications, 1993
- The IL-2 Receptor Complex: Its Structure, Function, and Target GenesAnnual Review of Immunology, 1993
- Disruption of the murine IL-4 gene blocks Th2 cytokine responsesNature, 1993
- Cloning of the γ Chain of the Human IL-2 ReceptorScience, 1992
- Cytokine Receptors and Signal TransductionAnnual Review of Immunology, 1992
- Generation and Analysis of Interleukin-4 Deficient MiceScience, 1991
- The proteins encoded by the VpreB and lambda 5 pre-B cell-specific genes can associate with each other and with mu heavy chain.The Journal of Experimental Medicine, 1990
- Absence of interleukin 2 production in a severe combined immunodeficiency disease syndrome with T cells.The Journal of Experimental Medicine, 1990
- Interactions between receptors for interleukin 2 and interleukin 4 on lines of helper T cells (HT-2) and B lymphoma cells (BCL1).The Journal of Experimental Medicine, 1989
- Interleukin-2: Inception, Impact, and ImplicationsScience, 1988