Regulatory T Cells Move in When Gliomas Say “I DO”
- 14 November 2012
- journal article
- editorial
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 18 (22), 6086-6088
- https://doi.org/10.1158/1078-0432.ccr-12-2801
Abstract
Indoleamine 2,3-dioxygenase (IDO) is an enzyme with known immunosuppressive and tolerogenic effects in cancer. Mounting evidence has associated IDO expression with the induction of regulatory T cells (Treg) and malignant progression. IDO inhibition may therefore provide a promising therapeutic approach for glioblastoma, where the need for novel treatment is great. Clin Cancer Res; 18(22); 6086–8. ©2012 AACR.Keywords
Other Versions
This publication has 12 references indexed in Scilit:
- IDO Expression in Brain Tumors Increases the Recruitment of Regulatory T Cells and Negatively Impacts SurvivalClinical Cancer Research, 2012
- A Pilot Study of IL-2Rα Blockade during Lymphopenia Depletes Regulatory T-cells and Correlates with Enhanced Immunity in Patients with GlioblastomaPLOS ONE, 2012
- Monoclonal antibody blockade of IL-2 receptor α during lymphopenia selectively depletes regulatory T cells in mice and humansBlood, 2011
- Site‐specific anti‐tumor immunity: Differences in DC function, TGF‐β production and numbers of intratumoral Foxp3+ TregEuropean Journal of Immunology, 2009
- CTLA-4 blockade with ipilimumab induces significant clinical benefit in a female with melanoma metastases to the CNSNature Clinical Practice Oncology, 2008
- Immunotherapy of malignant brain tumorsImmunological Reviews, 2008
- Systemic CTLA-4 Blockade Ameliorates Glioma-Induced Changes to the CD4+ T Cell Compartment without Affecting Regulatory T-Cell FunctionClinical Cancer Research, 2007
- Prolongation of survival following depletion of CD4+CD25+ regulatory T cells in mice with experimental brain tumorsJournal of Neurosurgery, 2006
- Systemic Anti-CD25 Monoclonal Antibody Administration Safely Enhances Immunity in Murine Glioma without Eliminating Regulatory T CellsClinical Cancer Research, 2006
- An increase in CD4+CD25+FOXP3+ regulatory T cells in tumor-infiltrating lymphocytes of human glioblastoma multiforme1Neuro-Oncology, 2006