Cytotoxic Prenylated Phenolic Compounds from the Twig Bark of Garcinia xanthochymus
- 18 May 2007
- journal article
- research article
- Published by Wiley in Chemistry & Biodiversity
- Vol. 4 (5), 940-946
- https://doi.org/10.1002/cbdv.200790083
Abstract
Three new hydroxylated xanthones with prenyl or geranyl substituents, compounds 1–3, were isolated from the twig bark of Garcinia xanthochymus, along with the four known compounds 1,4,5,6-tetrahydroxy-7,8-diprenylxanthone (4), 1,3,5,6-tetrahydroxy-4,7,8-triprenylxanthone (5), garciniaxanthone E (6), and 6-prenylapigenin (7). Their structures were elucidated by extensive spectroscopic analysis, including 1D- and 2D-NMR as well as HR-MS experiments. All compounds showed moderate cytotoxicities against breast cancer (MDA-MB-435S) and lung adenocarcinoma (A549) cell lines, but lacked antifungal activity against Candida albicans.This publication has 24 references indexed in Scilit:
- Bioactive Benzophenones from Garcinia xanthochymus FruitsJournal of Natural Products, 2005
- Prenylated xanthones with NGF-potentiating activity from Garcinia xanthochymusPhytochemistry, 2003
- Prenylated Xanthones from Garcinia xanthochymusCHEMICAL & PHARMACEUTICAL BULLETIN, 2003
- Caged-Tetraprenylated Xanthones from Garcinia scortechiniiTetrahedron, 2000
- Xanthones with Antimalarial Activity fromGarcinia dulcisPlanta Medica, 1998
- Isolation of biflavonoids with analgesic activity from Rheedia gardneriana leavesPhytomedicine, 1997
- Cytotoxic xanthones from Garcinia hanburyiPhytochemistry, 1996
- Influence of a series of natural flavonoids on free radical generating systems and oxidative stressXenobiotica, 1994
- Novel Prenylated Xanthones from Garcinia gerrardii HARVEYHelvetica Chimica Acta, 1989
- The constitution of xanthochymol and isoxanthochymolTetrahedron Letters, 1973