The evolution of isochores
- 1 July 2001
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Genetics
- Vol. 2 (7), 549-555
- https://doi.org/10.1038/35080577
Abstract
One of the most striking features of mammalian chromosomes is the variation in G+C content that occurs over scales of hundreds of kilobases to megabases, the so-called 'isochore' structure of the human genome. This variation in base composition affects both coding and non-coding sequences and seems to reflect a fundamental level of genome organization. However, although we have known about isochores for over 25 years, we still have a poor understanding of why they exist. In this article, we review the current evidence for the three main hypotheses.Keywords
This publication has 61 references indexed in Scilit:
- The Sequence of the Human GenomeScience, 2001
- Initial sequencing and analysis of the human genomeNature, 2001
- An Isochore Transition in the NF1 Gene Region Coincides with a Switch in the Extent of Linkage DisequilibriumAmerican Journal of Human Genetics, 2000
- Isochores and the evolutionary genomics of vertebratesGene, 1999
- Pattern of selective constraint in C. elegans and C. briggsae genomesGenetics Research, 1999
- Precise Switching of DNA Replication Timing in the GC Content Transition Area in the Human Major Histocompatibility ComplexMolecular and Cellular Biology, 1997
- Human Coding and Noncoding DNA: Compositional CorrelationsMolecular Phylogenetics and Evolution, 1996
- Correlations between the compositional properties of human genes, codon usage, and amino acid composition of proteinsJournal of Molecular Evolution, 1991
- The Mosaic Genome of Warm-Blooded VertebratesScience, 1985
- An analysis of the bovine genome by Cs2SO4—Ag+ density gradient centrifugationJournal of Molecular Biology, 1973