The Mg2+ transporter MagT1 partially rescues cell growth and Mg2+ uptake in cells lacking the channel-kinase TRPM7
Open Access
- 27 May 2011
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 585 (14), 2275-2278
- https://doi.org/10.1016/j.febslet.2011.05.052
Abstract
► We analyzed the role of the Mg2+ transporter MagT1 in DT40 B cells lacking the Mg2+ regulator TRPM7. ► Gene expression of MagT1 is upregulated in TRPM7−/− cells. ► Overexpressing MagT1 in TRPM7−/− ...Keywords
Funding Information
- National Institutes of Health Predoctoral Traineeship (R01GM068801, K08AI060926, R01GM90123)
This publication has 21 references indexed in Scilit:
- Magnesium Excretion in C. elegans Requires the Activity of the GTL-2 TRPM ChannelPLOS ONE, 2010
- Molecular identification of ancient and modern mammalian magnesium transportersAmerican Journal of Physiology-Cell Physiology, 2010
- Modulation of TRPM6 and Na+/Mg2+ exchange in mammary epithelial cells in response to variations of magnesium availabilityJournal of Cellular Physiology, 2009
- Deletion of Trpm7 Disrupts Embryonic Development and Thymopoiesis Without Altering Mg 2+ HomeostasisScience, 2008
- TRPM6 and TRPM7—Gatekeepers of human magnesium metabolismBiochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007
- SLC41A2 encodes a plasma-membrane Mg2+ transporterBiochemical Journal, 2006
- Identification and characterization of a novel mammalian Mg2+ transporter with channel-like propertiesBMC Genomics, 2005
- Magnesium: The missing element in molecular views of cell proliferation controlBioEssays, 2005
- Hypomagnesemia with secondary hypocalcemia is caused by mutations in TRPM6, a new member of the TRPM gene familyNature Genetics, 2002
- LTRPC7 is a Mg·ATP-regulated divalent cation channel required for cell viabilityNature, 2001