Targeting the canonical Wnt/β‐catenin pathway in hematological malignancies
Open Access
- 17 March 2015
- journal article
- review article
- Published by Wiley in Cancer Science
- Vol. 106 (6), 665-671
- https://doi.org/10.1111/cas.12655
Abstract
The canonical Wnt/β‐catenin pathway plays an important role in different developmental processes through the regulation of stem cell functions. In the activation of the canonical Wnt/β‐catenin pathway, β‐catenin protein is imported into the nucleus and activates transcription of target genes including cyclin D1 and c‐myc. Aberrant activation of the Wnt/β‐catenin pathway contributes to carcinogenesis and malignant behaviors, and Wnt signaling is essential for the maintenance of cancer stem cells. The canonical Wnt/β‐catenin pathway has been investigated extensively as a target in cancer treatment and several specific inhibitors of this signaling pathway have been identified through high‐throughput screening. In this review, the significance of the canonical Wnt/β‐catenin pathway in hematological carcinogenesis and screening methods for specific inhibitors are discussed.Keywords
This publication has 75 references indexed in Scilit:
- Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemiaBritish Journal of Cancer, 2011
- AV-65, a novel Wnt/β-catenin signal inhibitor, successfully suppresses progression of multiple myeloma in a mouse modelBlood Cancer Journal, 2011
- Orphan nuclear receptor TLX activates Wnt/β-catenin signalling to stimulate neural stem cell proliferation and self-renewalNature, 2009
- Tankyrase inhibition stabilizes axin and antagonizes Wnt signallingNature, 2009
- Wnt-Related Molecules and Signaling Pathway Equilibrium in HematopoiesisCell Stem Cell, 2009
- Wnt Signaling in the Niche Enforces Hematopoietic Stem Cell Quiescence and Is Necessary to Preserve Self-Renewal In VivoCell Stem Cell, 2008
- Loss of β-Catenin Impairs the Renewal of Normal and CML Stem Cells In VivoCancer Cell, 2007
- Targeting the β-catenin/TCF transcriptional complex in the treatment of multiple myelomaProceedings of the National Academy of Sciences, 2007
- Dynamics of chronic myeloid leukaemiaNature, 2005
- WNT and β-catenin signalling: diseases and therapiesNature Reviews Genetics, 2004