In-Stent Stenosis: Potential Role of Increased Oxidative Stress and Glutathione-Linked Detoxification Mechanisms
- 2 April 2008
- journal article
- research article
- Published by SAGE Publications in Angiology
- Vol. 59 (4), 469-474
- https://doi.org/10.1177/0003319707309651
Abstract
This study was designed to determine whether red-cell oxidative stress status and antioxidant enzyme levels can serve as markers in patients predisposed to in-stent stenosis. Blood was collected from patient groups undergoing coronary angiography for chest pain evaluation, namely, group A (without coronary artery disease), group B (previous coronary stents without in-stent stenosis), and group C (previous coronary stents with in-stent stenosis). Thiobarbituric acid reactive substances (measure of lipid peroxidation), glutathione-linked detoxification enzymes, catalase, and superoxide dismutase were determined. Compared with group A, patients in group C showed increased lipid peroxidation products and glutathione-S-transferase but decreased glutathione peroxidase and glutathione reductase activities. Results in group B patients were intermediate between those of groups A and C with significant decreases in glutathione peroxidase versus controls. In-stent stenosis is associated with significant increase in lipid peroxidation and attenuated glutathione-linked detoxification enzymes, consistent with oxidative stress.Keywords
This publication has 23 references indexed in Scilit:
- Low Daily Dose of Antioxidant Probucol Decreases Incidence and Severity of Restenosis after Transluminal Coronary Balloon AngioplastyBulletin of Experimental Biology and Medicine, 2005
- Oxidative stress and cardiac diseaseAmerican Journal Of Medicine, 2000
- Oxidative stress as a signaling mechanism of the vascular response to injury The redox hypothesis of restenosisCardiovascular Research, 2000
- Erythrocyte Selenium-Glutathione Peroxidase Activity Is Lower in Patients with Coronary Atherosclerosis.Japanese Heart Journal, 1997
- Investigation of erythrocyte membrane lipid peroxidation and antioxidant defense systems of patients with coronary artery disease (CAD) documented by angiographyClinica Chimica Acta; International Journal of Clinical Chemistry, 1996
- Glutathione-S-transferase of human red blood cells; assay, values in normal subjects and in two pathological circumstances: hyperbilirubinemia and impaired renal functionClinica Chimica Acta; International Journal of Clinical Chemistry, 1981
- [41] Preparation and assay of superioxide dismutasesMethods in enzymology, 1978
- Glutathione S-TransferasesJournal of Biological Chemistry, 1974
- Effect of flavin compounds on glutathione reductase activity: in vivo and in vitro studiesJCI Insight, 1969
- Estimation of product of lipid peroxidation (malonyl dialdehyde) in biochemical systemsAnalytical Biochemistry, 1966