Reinitiation of DNA synthesis in senescent human fibroblasts upon fusion with cells of unlimited growth potential.
Open Access
- 1 March 1975
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 64 (3), 551-556
- https://doi.org/10.1083/jcb.64.3.551
Abstract
Postreplicative, "senescent" human fibroblasts were fused to HeLa or to SV-40 transformed human fibroblasts with Sendai virus. DNA synthesis was reinitiated in senescent nuclei in a high proportion of the heterodikaryons. The [3H]thymidine labeling index of senescent fibroblast nuclei in heteropolykaryons was a function of the ratio of HeLa to senescent nuclei.Keywords
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