Transient retinoic acid signaling confers anterior-posterior polarity to the inner ear
- 20 December 2010
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 108 (1), 161-166
- https://doi.org/10.1073/pnas.1010547108
Abstract
Vertebrate hearing and balance are based in complex asymmetries of inner ear structure. Here, we identify retinoic acid (RA) as an extrinsic signal that acts directly on the ear rudiment to affect its compartmentalization along the anterior-posterior axis. A rostrocaudal wave of RA activity, generated by tissues surrounding the nascent ear, induces distinct responses from anterior and posterior halves of the inner ear rudiment. Prolonged response to RA by posterior otic tissue correlates with Tbx1 transcription and formation of mostly nonsensory inner ear structures. By contrast, anterior otic tissue displays only a brief response to RA and forms neuronal elements and most sensory structures of the inner ear.Keywords
This publication has 45 references indexed in Scilit:
- Mechanosensitive Hair Cell-like Cells from Embryonic and Induced Pluripotent Stem CellsCell, 2010
- Repression of Hedgehog signalling is required for the acquisition of dorsolateral cell fates in the zebrafish otic vesicleDevelopment, 2010
- Independent regulation of Sox3 and Lmx1b by FGF and BMP signaling influences the neurogenic and non-neurogenic domains in the chick otic placodeDevelopmental Biology, 2010
- How degrading: Cyp26s in hindbrain developmentDevelopmental Dynamics, 2008
- Ablation studies on the developing inner ear reveal a propensity for mirror duplicationsDevelopmental Dynamics, 2007
- Axial patterning in the developing vertebrate inner earThe International Journal of Developmental Biology, 2007
- Retinoic acid down‐regulates Tbx1 expression in vivo and in vitroDevelopmental Dynamics, 2005
- Control of retinoic acid synthesis and FGF expression in the nasal pit is required to pattern the craniofacial skeletonDevelopmental Biology, 2004
- Retinoic acid signalling in the development of branchial archesCurrent Opinion in Genetics & Development, 2004
- Naturally occurring and induced neuronal death in the chick embryo in vivo requires protein and RNA synthesis: Evidence for the role of cell death genesDevelopmental Biology, 1990