A fine structural comparison of the healing of incisional wounds of mucosa and skin
- 1 July 1978
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 7 (4), 214-227
- https://doi.org/10.1111/j.1600-0714.1978.tb01596.x
Abstract
Incisional wounds of the same length and depth were made on tongue and dorsal skin of rats and the fine structural aspects of the responses of these were compared. Comparisons were made between the timing and degree of phagocytosis, the timing and rate of epithelial cell migration, overall rate of healing and reformation of basal lamina and attachment complex in these 2 tissues. Phagocytic activity in epithelium and connective tissue of mucosa reached higher levels than in skin and the peak of activity in the epithelium of the mucosa was earlier than in the epidermis. Mononuclear phagocytes were active in phagocytosis; neutrophils showed little phagocytic activity. Epithelial migration began earlier in mucosa than in skin. Epithelialization of the wound and repair of supporting tissue were completed earlier. The same sequence in the renewal of ultrastructural components of the hemidesmosome-attachment complex was found in skin and mucosa, but was completed earlier at the mucosal site. Mechanical, physical and physiologic factors may play a role in determining the differing rates of repair in mucosa and skin.This publication has 18 references indexed in Scilit:
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