An abnormal membrane glycoprotein associated with malignancy in a wide range of different tumours
Open Access
- 13 April 1978
- journal article
- research article
- Published by The Royal Society in Proceedings of the Royal Society of London. B. Biological Sciences
- Vol. 201 (1142), 87-106
- https://doi.org/10.1098/rspb.1978.0034
Abstract
Malignancy, as measured by the ability of cells to grow progressively in vivo, is intimately linked to the presence of a structural abnormality in the polysaccharide moiety of one particular membrane glycoprotein. This abnormality is present in a wide range of different tumours; it cosegregates with malignancy in all crosses between malignant and non-malignant cells that have so far been tested; and it remains linked to malignancy in a stringent new test in which non-malignant variants are selected from tumour cell populations by the use of a lectin.This publication has 32 references indexed in Scilit:
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