Unimpaired Thymic and Peripheral T Cell Death in Mice Lacking the Nuclear Receptor NGFI-B (Nur77)
- 28 July 1995
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 269 (5223), 532-535
- https://doi.org/10.1126/science.7624775
Abstract
T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for negative selection of self-reactive T cells. TCR-mediated death was examined in mice bearing an NGFI-B loss-of-function mutation, either by administration of antibodies to CD3 (anti-CD3) or in two well-characterized transgenic models expressing self-reactive TCRs. Both the extent and the rate of thymocyte death were unimpaired. Anti-CD3-induced death was normal in CD4+ peripheral T cells, in which death is mediated predominantly by the Fas signaling pathway. Thus, no unique requirement for NGFI-B is observed for thymic or peripheral T cell death.Keywords
This publication has 24 references indexed in Scilit:
- Growth and Differentiation Proceeds Normally in Cells Deficient in the Immediate Early Gene NGFI-AJournal of Biological Chemistry, 1995
- Fas(CD95)/FasL interactions required for programmed cell death after T-cell activationNature, 1995
- Cell-autonomous Fas (CD95)/Fas-ligand interaction mediates activation-induced apoptosis in T-cell hybridomasNature, 1995
- Autocrine T-cell suicide mediated by APO-1/(Fas/CD95)Nature, 1995
- T-cell apoptosis detected in situ during positive and negative selection in the thymusNature, 1994
- Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77Nature, 1994
- Requirement for the orphan steroid receptor Nur77 in apoptosis of T-cell hybridomasNature, 1994
- Role for c-myc in Activation-Induced Apoptotic Cell Death in T Cell HybridomasScience, 1992
- Antibodies to CD3/T-cell receptor complex induce death by apoptosis in immature T cells in thymic culturesNature, 1989
- Deletion of self-reactive T cells before entry into the thymus medullaNature, 1988