Pharmacologic intervention in ischemia‐induced reperfusion injury in the skeletal muscle

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Abstract
This article provides a concise review on the potential causes of ischemia‐induced reperfusion (I/R) injury and pharmacologic intervention in the skeletal muscle. Special emphasis is placed on the recent observation of the acute ischemic preconditioning phenomenon for prevention of I/R injury in skeletal muscle. Finally, the mechanism of ischemic preconditioning and its clinical applications for augmentation of skeletal muscle tolerance to prolonged ischemic insult are discussed. © 1993 Wiley‐Liss Inc.