Hyperreactivity of Neutrophils and Abnormal T Cell Homeostasis: a New Insight for Pathogenesis of Behçet's Disease
- 1 January 1997
- journal article
- review article
- Published by Informa UK Limited in International Reviews of Immunology
- Vol. 14 (1), 11-19
- https://doi.org/10.3109/08830189709116841
Abstract
Neutrophil hyperfunction of Behçet's disease is in part regulated by genetical factors, especially related to HLA-B51 genes and by immunological abnormalities. Regarding the latter points, Behçet's disease worsens with abnormal regulation by γδ T cells and αβ T cells. Indeed, our own studies and those of other laboratories suggest that human heat shock protein may be one of the triggering factors for activation of both the γδ T cells and αβ T cells. These activated T cells may produce proinflammatory and/or inflammatory cytokines, and lead to tissue injury possibly via delayed-type hypersensitivity reaction, macrophage activation, and activation and/or recruitment of neutrophils. Here we discuss the crosstalk between the immune system and neutrophils in this disease.Keywords
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