Cancer-Related Fatigue: The Scale of the Problem
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Open Access
- 1 May 2007
- journal article
- review article
- Published by Oxford University Press (OUP) in The Oncologist
- Vol. 12 (S1), 4-10
- https://doi.org/10.1634/theoncologist.12-s1-4
Abstract
Fatigue is one of the most common and debilitating symptoms experienced by patients with cancer. Cancer-related fatigue (CRF) is characterized by feelings of tiredness, weakness, and lack of energy, and is distinct from the “normal” drowsiness experienced by healthy individuals in that it is not relieved by rest or sleep. It occurs both as a consequence of the cancer itself and as a side effect of cancer treatment, although the precise underlying pathophysiology is largely unknown. CRF may be an early symptom of malignant disease and is reported by as many as 40% of patients at diagnosis. Virtually all patients expect fatigue from cancer therapy. Up to 90% of patients treated with radiation and up to 80% of those treated with chemotherapy experience fatigue. CRF continues for months and even years ollowing completion of treatment in approximately one third of the patients with cancer. The impact of CRF on a patient's quality of life (QoL), particularly in relation to physical functioning and the ability to perform activities of daily living, is both profound and pervasive. In addition, CRF is associated with considerable psychological distress and can impose a significant financial burden by limiting a patient's ability to work. These effects can extend to caregivers and family members, who may also have to reduce their working capacity in order to provide additional care for a patient with CRF. This paper examines the prevalence of CRF and explores the impact of this distressing symptom on patients' functioning and QoL. Disclosure of potential conflicts of interest is found at the end of this article.Keywords
Funding Information
- NCI (1R25-CA102618-01A1, 2U10 CA037420-20)
- American Cancer Society (RSG01071-01-PBP)
- Cephalon, Inc., Frazer, PA
This publication has 44 references indexed in Scilit:
- Cases and Materials on the English Legal SystemPublished by Cambridge University Press (CUP) ,2007
- Management of Cancer-Related FatigueCancer Investigation, 2005
- Cancer-Related Fatigue: Prevalence of Proposed Diagnostic Criteria in a United States Sample of Cancer SurvivorsJournal of Clinical Oncology, 2001
- Fatigue and Psychiatric Morbidity Among Hodgkin's Disease SurvivorsJournal of Pain and Symptom Management, 2000
- Fatigue in advanced cancer: a prospective controlled cross-sectional studyBritish Journal of Cancer, 1999
- Fatigue and radiotherapy: (A) experience in patients undergoing treatmentBritish Journal of Cancer, 1998
- Fatigue and radiotherapy: (B) experience in patients 9 months following treatmentBritish Journal of Cancer, 1998
- Characteristics and correlates of fatigue after adjuvant chemotherapy for breast cancer.Journal of Clinical Oncology, 1998
- Off-Treatment Fatigue in Breast Cancer Survivors: A Controlled ComparisonJournal of Behavioral Medicine, 1998
- A qualitative study to explore the concept of fatigue/tiredness in cancer patients and in healthy individualsSupportive Care in Cancer, 1996