Chagas Heart Disease
- 1 March 2012
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Cardiology in Review
- Vol. 20 (2), 53-65
- https://doi.org/10.1097/crd.0b013e31823efde2
Abstract
Chagas disease, caused by the parasite Trypanosoma cruzi, is an important cause of cardiac disease in endemic areas of Latin America. It is now being diagnosed in nonendemic areas because of immigration. Typical cardiac manifestations of Chagas disease include dilated cardiomyopathy, congestive heart failure, arrhythmias, cardioembolism, and stroke. Clinical and laboratory-based research to define the pathology resulting from T. cruzi infection has shed light on many of the cellular and molecular mechanisms leading to these manifestations. Antiparasitic treatment may not be appropriate for patients with advanced cardiac disease. Clinical management of Chagas heart disease is similar to that used for cardiomyopathies caused by other processes. Cardiac transplantation has been successfully performed in a small number of patients with Chagas heart disease.Keywords
This publication has 137 references indexed in Scilit:
- Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas diseaseMicrobes and Infection, 2011
- The Vasculature in Chagas DiseaseAdvances in Parasitology, 2011
- Phenyl-α-tert-butyl-nitrone and Benzonidazole Treatment Controlled the Mitochondrial Oxidative Stress and Evolution of Cardiomyopathy in Chronic Chagasic RatsJournal of the American College of Cardiology, 2010
- Chagas diseaseThe Lancet, 2010
- The role of selenium in intestinal motility and morphology in a murine model of Typanosoma cruzi infectionZeitschrift für Parasitenkunde, 2010
- CD8+ T cells in Trypanosoma cruzi infectionCurrent Opinion in Immunology, 2009
- Perspectives on Trypanosoma cruzi–Induced Heart Disease (Chagas Disease)Progress in Cardiovascular Diseases, 2009
- Nitric oxide synthase-2 modulates chemokine production by Trypanosoma cruzi-infected cardiac myocytesMicrobes and Infection, 2008
- Tissue-specific oxidative imbalance and mitochondrial dysfunction during Trypanosoma cruzi infection in miceMicrobes and Infection, 2008
- Dyskinesis in chagasic myocardium: centerline analysis of wall motion using cardiac-gated magnetic resonance images of miceMagnetic Resonance Imaging, 2006