LOCALIZATION OF BROWN RECLUSE VENOM ATTACHMENT SITES ON HUMAN-ERYTHROCYTES BY THE FERRITIN-LABELED ANTIBODY TECHNIQUE

  • 1 January 1979
    • journal article
    • research article
    • Vol. 95 (3), 675-+
Abstract
Brown recluse spider (Loxosceles reclusa) venom was demonstrated by a ferritin-labeled antibody technique to attach to human erythrocyte cell membranes. The number of individual attachment sites/cell is proportional to the concentration of the venom used to sensitize the erythrocyte. Structural changes in the red cell membrane are associated with the venom attachment. These sites may be related to the red cell hemolysis which sometimes occurs in the human as a result of the spider bite.