Magnetic mesoporous bioactive glass scaffolds: preparation, physicochemistry and biological properties
- 1 January 2013
- journal article
- Published by Royal Society of Chemistry (RSC) in Journal of Materials Chemistry B
- Vol. 1 (9), 1279-1288
- https://doi.org/10.1039/c2tb00262k
Abstract
The magnetic 10Fe5Ca MBG scaffolds (Fe3O4–CaO–SiO2–P2O5 system) have been prepared by a combination of polyurethane sponge and P123 as co-templates and an evaporation-induced self-assembly (EISA) process through the substitution of Fe3O4 for CaO in the 15Ca MBG scaffolds (CaO–SiO2–P2O5 system). The structure, magnetic heating, drug release, physicochemical and biological properties were systematically investigated. The results showed that the 10Fe5Ca MBG scaffolds had the interconnected macroporous structure with pore sizes ranging from 200 to 400 μm and the mesoporous wall with a peak pore size of ca. 3.34 nm. Also, the 10Fe5Ca MBG scaffolds exhibited similar mechanical strength, apatite-forming ability and sustained drug release behavior compared to the 15Ca MBG scaffolds. Importantly, the substitution of Fe3O4 for CaO in the MBG scaffolds induced a slower ion dissolution rate and more significant potential to stabilize the pH environment, and facilitated osteoblast cell proliferation, alkaline phosphatase (ALP) activity and osteogenic expression. In particular, the 10Fe5Ca MBG scaffolds could generate heat in an alternating magnetic field. Therefore, the magnetic 10Fe5Ca MBG scaffolds have potential for the regeneration of the critical-size bone defects caused by bone tumors by a combination of magnetic hyperthermia and local drug delivery therapy.Keywords
This publication has 57 references indexed in Scilit:
- Magnetic responsive hydroxyapatite composite scaffolds construction for bone defect reparationInternational Journal of Nanomedicine, 2012
- Magnetic Hydroxyapatite Bone Substitutes to Enhance Tissue Regeneration: Evaluation In Vitro Using Osteoblast-Like Cells and In Vivo in a Bone DefectPLOS ONE, 2012
- The use of bone-graft substitutes in large bone defects: Any specific needs?Injury, 2011
- Magnetic bioactive glass ceramic in the system CaO–P2O5–SiO2–MgO–CaF2–MnO2–Fe2O3 for hyperthermia treatment of bone tumorJournal of Materials Science: Materials in Medicine, 2011
- Magnetic mesoporous silica spheres for hyperthermia therapyActa Biomaterialia, 2010
- A novel route in bone tissue engineering: Magnetic biomimetic scaffoldsActa Biomaterialia, 2009
- Bisphosphonates reduce local recurrence in extremity giant cell tumor of bone: A case–control studyBone, 2008
- Sol–gel synthesis of bioactive glass scaffolds for tissue engineering: Effect of surfactant type and concentrationJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2005
- Factors affecting the structure and properties of bioactive foam scaffolds for tissue engineeringJournal of Biomedical Materials Research Part B: Applied Biomaterials, 2003
- Biphasic materials for bone grafting and hyperthermia treatment of cancerJournal of Biomedical Materials Research Part A, 2003