Calcium-Dependent Norepinephrine Release from Presynaptic Nerve Endings In Vitro
- 1 August 1972
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 69 (8), 2237-2240
- https://doi.org/10.1073/pnas.69.8.2237
Abstract
Potassium concentrations above 15-20 mM in the medium, or addition of 75 muM veratridine to medium that contains 5 mM K, stimulate calcium accumulation and Ca-dependent norepinephrine release by presynaptic nerve terminals (synaptosomes) incubated in vitro. The effects of veratridine, but not of K, are blocked by 0.2 muM tetrodotoxin. This association between Ca entry and norepinephrine release is consistent with the Calcium Hypothesis of transmitter release. These results add further evidence that synaptosomes may retain many functional properties of intact presynaptic endings.Keywords
This publication has 26 references indexed in Scilit:
- Batrachotoxin: Chemistry and PharmacologyScience, 1971
- METABOLISM OF GLUCOSE AND GLUTAMATE BY SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEXJournal of Neurochemistry, 1969
- Release of noradrenaline from the cat spleen by potassiumThe Journal of Physiology, 1968
- The osmotically sensitive potassium and sodium compartments of synaptosomesBiochemical Journal, 1967
- Release of noradrenaline by splenic nerve stimulation and its dependence on calciumThe Journal of Physiology, 1967
- A sensitive method for spectrophotofluorometric assay of catecholaminesInternational Journal of Neuropharmacology, 1964
- The subcellular localization of 5-hydroxytryptamine in guinea pig brainBiochemical Pharmacology, 1963
- [Noradrenalin loss from the isolated rabbit heart following sympathetic nerve irritation and its pharmacological alteration].1962
- ISOLATION OF NERVE ENDINGS FROM BRAIN - AN ELECTRON-MICROSCOPIC STUDY OF CELL FRAGMENTS DERIVED BY HOMOGENIZATION AND CENTRIFUGATION1962
- The role of calcium in the secretory response of the adrenal medulla to acetylcholineThe Journal of Physiology, 1961