Determination of Melatonin in Commercially Available Products by LCEC and LC/MS/MS
- 1 May 1998
- journal article
- research article
- Published by Informa UK Limited in Journal of Liquid Chromatography & Related Technologies
- Vol. 21 (9), 1273-1282
- https://doi.org/10.1080/10826079808005877
Abstract
Simple and reliable methods for liquid chromatography/electrochemistry (LCEC) and LC/MS/MS with atmospheric pressure chemical ionization (APCI) have been developed for the determination of melatonin in commercially available products. The dissolution of melatonin from the melatonin-containing formulations was simply obtained by dissolving the tablets and capsules in 20% acetonitrile in 0.1 N perchloric acid with ultrasonication. The filtrate of the resultant solution was separated on a 1 × 150 mm CKeywords
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