The effects of an enhanced inflammatory reaction on the surface properties of cast biomer
- 1 February 1986
- journal article
- research article
- Published by Wiley in Journal of Biomedical Materials Research
- Vol. 20 (2), 153-168
- https://doi.org/10.1002/jbm.820200205
Abstract
The ability of a biomaterial to withstand the rigors of the harsh biologic environment is an important consideration when considering a material for long‐term biomedical applications. Using a cage implant system, the effects of an intense inflammatory reaction on cast Biomer have been investigated. The inflammatory response to cast Biomer was greatly increased by coimplanting Biomer films with a cytotoxic poly(vinyl chloride) (PVC) in rats for a period of 21 days. Cast Biomer films were characterized by weight, advancing contact angle with water in air, attenuated total reflectance infrared spectroscopy and scanning electron microscopy (SEM). The analyses were performed before any treatment, after autoclaving and sonication, and after 21 days implantation with the cytotoxic (PVC) in rats. The results of the study indicated that cast Biomer does not undergo significant chemical degradation when subjected to the effects of an intense inflammatory reaction for 21 days. Implantation does, however, lead to rearrangement that results in a more polar and hydrophilic surface, suggesting that the polymer adapts to the hydrophilic environment of the inflammatory exudate.Keywords
This publication has 15 references indexed in Scilit:
- In vivo biocompatibility studies. VII. Inflammatory response to polyethylene and to a cytotoxic polyvinylchlorideJournal of Biomedical Materials Research, 1986
- In vivo biocompatibility studies. V. In vivo leukocyte interactions with biomerJournal of Biomedical Materials Research, 1984
- In vivo biocompatibility studies. II. Biomer: Preliminary cell adhesion and surface characterization studiesJournal of Biomedical Materials Research, 1984
- Physicochemical characterization and in vivo blood tolerability of cast and extruded biomerJournal of Biomedical Materials Research, 1983
- The Effect of Polyether Segment Molecular Weight on the Bulk and Surface Morphologies of Copolyether-Urethane-UreasPublished by American Chemical Society (ACS) ,1982
- Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins, and collagen by proteinases isolated from macrophages.The Journal of Experimental Medicine, 1980
- Least-Squares Curve-Fitting of Fourier Transform Infrared Spectra with Applications to Polymer SystemsApplied Spectroscopy, 1977
- Polyester readily hydrolyzable by chymotrypsinJournal of Polymer Science Part C: Polymer Letters, 1975
- Tissue pathology and physical stability of a polyether elastomer on three‐year implantationJournal of Biomedical Materials Research, 1972
- Segmented polyurethane: A polyether polymer. An initial evalution for biomedical applicationsJournal of Biomedical Materials Research, 1968