INCREASED URINARY EXCRETION OF ENDOTHELIN DURING HYPOTHERMIC PERFUSION PRESERVATION IN KIDNEYS SUBJECTED TO PRERETRIEVAL WARM ISCHEMIC INJURY
- 1 May 2000
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Transplantation
- Vol. 69 (10), 2187-2190
- https://doi.org/10.1097/00007890-200005270-00039
Abstract
The purpose of the study was two-fold: 1) to determine whether endothelin (ET) levels could be detected in the ureteral effluent during hypothermic perfusion preservation (HPP) and; 2) to determine whether preretrieval warm ischemic (WI) injury is associated with increased ureteral excretion of ET. In situ pre-WI injury was induced in Lewis rats (n=10) by a 30-min extrinsic occlusion of the suprarenal aorta. The left kidney underwent 16 hr of HPP, and ureteral effluent (UE) from ischemic and control kidneys (n=10) was collected over 16 hr of HPP. The UE ET concentration and total ET excretion over 16 hr of HPP were significantly higher in kidneys subjected to pre-WI injury compared with nonischemic controls. Kidneys subjected to pre-WI injury can be distinguished from nonischemic control kidneys during HPP by a significantly higher concentration of ET in the UE and a higher overall excretion of ET during HPP.Keywords
This publication has 8 references indexed in Scilit:
- Cold Ischemia Induces Endothelin Gene Upregulation in the Preserved KidneyJournal of Surgical Research, 1999
- Endothelin up-regulation and localization following renal ischemia and reperfusionKidney International, 1999
- Economic impact of delayed graft function and suboptimal kidneysTransplantation Reviews, 1999
- THE USE OF A NOVEL MONITORING APPARATUS AND MODIFIED BELZER HYDROXYETHYL STARCH PERFUSATE FOR ANALYSIS OF GLOMERULAR FILTRATION DURING HYPOTHERMIC PERFUSION PRESERVATION1Transplantation, 1996
- Paracrine regulation of the renal microcirculationPhysiological Reviews, 1996
- Effect of Hypothermia on Intracellular Ca2+in Rabbit Renal Tubules Suspended in UW-Gluconate Preservation SolutionCryobiology, 1996
- In Vivo Effects of Endothelin on the Renal MicrocirculationJournal of Surgical Research, 1993
- Relative Preservation of the Responsiveness to Endothelin-1 During Reperfusion Following Renal Ischemia in the RatJournal of Cardiovascular Pharmacology, 1991