Carbonic anhydrases in normal gastrointestinal tract and gastrointestinal tumours
Open Access
- 1 January 2005
- journal article
- review article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastroenterology
- Vol. 11 (2), 155-163
- https://doi.org/10.3748/wjg.v11.i2.155
Abstract
Carbonic anhydrases (CAs) catalyse the hydration of CO2 to bicarbonate at physiological pH. This chemical interconversion is crucial since HCO3- is the substrate for several biosynthetic reactions. This review is focused on the distribution and role of CA isoenzymes in both normal and pathological gastrointestinal (GI) tract tissues. It has been known for many years that CAs are widely present in the GI tract and play important roles in several physiological functions such as production of saliva, gastric acid, bile, and pancreatic juice as well as in absorption of salt and water in intestine. New information suggests that these enzymes participate in several processes that were not envisioned earlier. Especially, the recent reports on plasma membrane-bound isoenzymes IX and XII have raised considerable interest since they were reported to participate in cancer invasion and spread. They are induced by tumour hypoxia and may also play a role in von Hippel-Lindau (VHL)-mediated carcinogenesis.Keywords
This publication has 120 references indexed in Scilit:
- The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer CellsCell, 2002
- Carbonic Anhydrase II Binds to and Enhances Activity of the Na+/H+ ExchangerJournal of Biological Chemistry, 2002
- The Extracellular Component of a Transport MetabolonPublished by Elsevier BV ,2002
- Gustin from Human Parotid Saliva Is Carbonic Anhydrase VIBiochemical and Biophysical Research Communications, 1998
- Immunohistochemical Study of Colorectal Tumors for Expression of a Novel Transmembrane Carbonic Anhydrase, MN/CA IX, with Potential Value as a Marker of Cell ProliferationThe American Journal of Pathology, 1998
- Carbonic Anhydrase Isoenzymes I, II, III, and IV Are Present in Human Esophageal EpitheliumJournal of Histochemistry & Cytochemistry, 1997
- Membrane-bound carbonic anhydrase IV is expressed in the luminal plasma membrane of the human gallbladder epitheliumHepatology, 1996
- Expression of Mouse Carbonic Anhydrase VII inE. coliand Demonstration of Its CO2Hydrase ActivityBiochemical and Biophysical Research Communications, 1996
- Genomic Organization and Localization of Gene for Human Carbonic Anhydrase IV to Chromosome 17qGenomics, 1993
- Carbonic Anhydrase II Deficiency in 12 Families with the Autosomal Recessive Syndrome of Osteopetrosis with Renal Tubular Acidosis and Cerebral CalcificationNew England Journal of Medicine, 1985