Effect of Leukocyte Interferon on Urinary Excretion of Cytomegalovirus by Infants

Abstract

Five infants with symptomatic cytomegalovirus infections and high urinary titers of cytomegalovirus were treated with interferon in doses of 1.7–3.5 x 10⁵ reference units/kg per day for seven to 14 days. Six courses of treatment were given. One of two infants treated with the largest dose of interferon had transient suppression of viruria; no suppression was noted during the other five courses of treatment. Adverse effects noted included a low rate of weight gain, a transient elevation of serum aspartate aminotransferase and fever. Further trials are needed to determine whether larger doses of a more purified preparation of interferon will eliminate viruria in infants with cytomegalovirus infection, but careful assessment of toxicity will be necessary in this population of patients.