Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria
Top Cited Papers
- 21 May 2018
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Microbiology
- Vol. 3 (6), 687-697
- https://doi.org/10.1038/s41564-018-0162-2
Abstract
Plasmodium falciparum, the most virulent agent of human malaria, shares a recent common ancestor with the gorilla parasite Plasmodium praefalciparum. Little is known about the other gorilla- and chimpanzee-infecting species in the same (Laverania) subgenus as P. falciparum, but none of them are capable of establishing repeated infection and transmission in humans. To elucidate underlying mechanisms and the evolutionary history of this subgenus, we have generated multiple genomes from all known Laverania species. The completeness of our dataset allows us to conclude that interspecific gene transfers, as well as convergent evolution, were important in the evolution of these species. Striking copy number and structural variations were observed within gene families and one, stevor, shows a host-specific sequence pattern. The complete genome sequence of the closest ancestor of P. falciparum enables us to estimate the timing of the beginning of speciation to be 40,000–60,000 years ago followed by a population bottleneck around 4,000–6,000 years ago. Our data allow us also to search in detail for the features of P. falciparum that made it the only member of the Laverania able to infect and spread in humans.This publication has 81 references indexed in Scilit:
- Effective/census population size ratio estimation: a compendium and appraisalEcology and Evolution, 2012
- Bayesian inference of ancient human demography from individual genome sequencesNature Genetics, 2011
- Origin of the human malaria parasite Plasmodium falciparum in gorillasNature, 2010
- Evidence for an ancient adaptive episode of convergent molecular evolutionProceedings of the National Academy of Sciences, 2009
- The Dawn of Human Matrilineal DiversityAmerican Journal of Human Genetics, 2008
- A family affair: var genes, PfEMP1 binding, and malaria diseaseCurrent Opinion in Microbiology, 2006
- OrthoMCL: Identification of Ortholog Groups for Eukaryotic GenomesGenome Research, 2003
- Genome sequence of the human malaria parasite Plasmodium falciparumNature, 2002
- Statistics of local complexity in amino acid sequences and sequence databasesComputers & Chemistry, 1993
- Adaptive protein evolution at the Adh locus in DrosophilaNature, 1991