Siderosis of lymph nodes in patients with Hodgkin's disease
- 1 September 1976
- Vol. 38 (3), 1247-1252
- https://doi.org/10.1002/1097-0142(197609)38:3<1247::aid-cncr2820380326>3.0.co;2-z
Abstract
Lymph nodes removed from 28 untreated patients with Hodgkin's disease all contained markedly increased amounts of hemosiderin, whether or not they were histologically involved in the disease. This finding was particularly striking in patients with the nodular sclerosis type of disease. Abnormal deposits of iron were also noted frequently in lymph nodes containing metastatic carcinoma, lymphoma of non-Hodgkin's type, and reactive hyperplasia, but in each case, with the exception of metastatic squamous cell carcinoma, the amount was significantly less than that seen in Hodgkin's disease. The findings suggest that in patients with Hodgkin's disease and perhaps in those with other disorders in which abnormal tissue retention of iron underlies sideropenic anemia, lymph nodes are an important site of iron retention.This publication has 13 references indexed in Scilit:
- Ferritin, a Hodgkin's Disease Associated AntigenProceedings of the National Academy of Sciences, 1974
- Serum ferritin concentration as an index of storage iron in rheumatoid arthritisJournal of Clinical Pathology, 1974
- The role of splenectomy in the management of advanced hodgkin's diseaseCancer, 1974
- Ferritinaemia in Leukaemia and Hodgkin's DiseaseBritish Journal of Cancer, 1973
- Iron Metabolism in Hodgkin's DiseaseBritish Journal of Cancer, 1972
- The Measurement of Reticuloendothelial Iron Release using Iron–DextranBritish Journal of Haematology, 1971
- Annotation: THE ANAEMIA OF CHRONIC DISORDERSBritish Journal of Haematology, 1971
- Circulating Iron-Containing Macrophages in HemochromatosisNew England Journal of Medicine, 1968
- The Exchange of Iron with Interstitial Fluid.Experimental Biology and Medicine, 1964
- Exchange of iron and transferrin across endothelial surfaces in the rat and rabbitThe Journal of Physiology, 1963