Structure and function of the human calcium‐sensing receptor: insights from natural and engineered mutations and allosteric modulators
Open Access
- 1 September 2007
- journal article
- review article
- Published by Wiley in Journal of Cellular and Molecular Medicine
- Vol. 11 (5), 908-922
- https://doi.org/10.1111/j.1582-4934.2007.00096.x
Abstract
The human extracellular Ca2+-sensing receptor (CaR), a member of the G protein-coupled receptor family 3, plays a key role in the regulation of extracellular calcium homeostasis. It is one of just a few G protein-coupled receptors with a large number of naturally occurring mutations identified in patients. In contrast to the small sizes of its agonists, this large dimeric receptor consists of domains with topologically distinctive orthos-teric and allosteric sites. Information derived from studies of naturally occurring mutations, engineered mutations, allosteric modulators and crystal structures of the agonist-binding domain of homologous type 1 metabotropic glutamate receptor and G protein-coupled rhodopsin offers new insights into the structure and function of the CaR.Keywords
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