Update on overactive bladder: Pharmacologic approaches on the horizon
- 1 October 2003
- journal article
- review article
- Published by Springer Science and Business Media LLC in Current Urology Reports
- Vol. 4 (5), 385-390
- https://doi.org/10.1007/s11934-003-0013-3
Abstract
Limitations exist with regard to the array of available agents for the pharmacologic therapy of overactive bladder, including issues of efficacy and tolerability. It is clear that the ideal agent for this condition has not been identified. However, several new pharmacologic treatments, including some with novel approaches to drug delivery, have emerged in clinical development over the past few years. These agents include a variety of anticholinergics and others. In initial studies, some of the agents appear to compare favorably with existing therapies. Whether these promising results will hold up when subjected to large-scale, well-controlled clinical trials is unclear.Keywords
This publication has 39 references indexed in Scilit:
- Current and Future Pharmacological Treatment for Overactive BladderJournal of Urology, 2002
- Efficacy and Safety of Transdermal Oxybutynin in Patients With Urge and Mixed Urinary IncontinenceJournal of Urology, 2002
- Anticholinergic drugs versus placebo for overactive bladder syndrome in adultsPublished by Wiley ,2002
- A SHORT-TERM, MULTICENTER, RANDOMIZED DOUBLE-BLIND DOSE TITRATION STUDY OF THE EFFICACY AND ANTICHOLINERGIC SIDE EFFECTS OF TRANSDERMAL COMPARED TO IMMEDIATE RELEASE ORAL OXYBUTYNIN TREATMENT OF PATIENTS WITH URGE URINARY INCONTINENCEJournal of Urology, 2001
- BOTULINUM-A TOXIN FOR TREATING DETRUSOR HYPERREFLEXIA IN SPINAL CORD INJURED PATIENTS: A NEW ALTERNATIVE TO ANTICHOLINERGIC DRUGS? PRELIMINARY RESULTSJournal of Urology, 2000
- Efficacy of trospium chloride in patients with detrusor instability: a placebo‐controlled, randomized, double‐blind, multicentre clinical trialBJU International, 2000
- Urothelium‐derived inhibitory factor(s) influences on detrusor muscle contractility in vitroBritish Journal of Pharmacology, 2000
- Intravesical Instillation of Oxybutynin Hydrochloride for Detrusor Hyper‐reflexiaPublished by Wiley ,1993
- Measurement of oxybutynin and its N-desethyl metabolite in plasma, and its application to pharmacokinetic studies in young, elderly and frail elderly volunteersXenobiotica, 1992
- Effect of Trospium Chloride on Urodynamic Parameters in Patients with Detrusor Hyperreflexia due to Spinal Cord InjuriesUrologia Internationalis, 1991