A Perspective on Polylactic Acid-Based Polymers Use for Nanoparticles Synthesis and Applications
Top Cited Papers
Open Access
- 10 October 2019
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Bioengineering and Biotechnology
- Vol. 7, 259
- https://doi.org/10.3389/fbioe.2019.00259
Abstract
Polylactic acid (PLA)-based polymers are ubiquitous in the biomedical field thanks to their combination of attractive peculiarities: biocompatibility (degradation products do not elicit critical responses and are easily metabolized by the body), hydrolytic degradation in situ, tailorable properties, and well-established processing technologies. This led to the development of several applications, such as bone fixation screws, bioresorbable suture threads, and stent coating, just to name a few. Nanomedicine could not be unconcerned by PLA-based materials as well, where their use for the synthesis of nanocarriers for the targeted delivery of hydrophobic drugs emerged as a new promising application. The purpose of the here presented review is two-fold: on one side, it aims at providing a broad overview of PLA-based materials and their properties, which allow them gaining a leading role in the biomedical field; on the other side, it offers a specific focus on their recent use in nanomedicine, highlighting opportunities and perspectives.Keywords
Funding Information
- Kommission für Technologie und Innovation
This publication has 84 references indexed in Scilit:
- Endocytosis of nanomedicinesJournal of Controlled Release, 2010
- PEGylation strategies for active targeting of PLA/PLGA nanoparticlesJournal of Biomedical Materials Research Part A, 2008
- Brain transport of neurotoxin‐I with PLA nanoparticles through intranasal administration in rats: a microdialysis studyBiopharmaceutics & Drug Disposition, 2008
- Immunological properties of engineered nanomaterialsNature Nanotechnology, 2007
- Biodegradable Nanogel Formation of Polylactide-Grafted Dextran Copolymer in Dilute Aqueous Solution and Enhancement of Its Stability by StereocomplexationBiomacromolecules, 2007
- Understanding the nanoparticle–protein corona using methods to quantify exchange rates and affinities of proteins for nanoparticlesProceedings of the National Academy of Sciences, 2007
- Synthesis of a biodegradable tadpole-shaped polymer via the coupling reaction of polylactide onto mono(6-(2-aminoethyl)amino-6-deoxy)-β-cyclodextrin and its properties as the new carrier of protein delivery systemJournal of Controlled Release, 2005
- Role of zinc in formulation of PLGA/PLA nanoparticles encapsulating betamethasone phosphate and its release profileJournal of Controlled Release, 2005
- Improved entrapment efficiency of hydrophilic drug substance during nanoprecipitation of poly(I)lactide nanoparticlesAAPS PharmSciTech, 2004
- Synthesis of a novel fluorescent poly(?,?-lactide) end-capped with 1-pyrenebutanol used for the preparation of nanoparticlesEuropean Journal of Pharmaceutical Sciences, 2003