Fisher syndrome or Bickerstaff brainstem encephalitis? Anti‐GQ1b IgG antibody syndrome involving both the peripheral and central nervous systems
- 30 September 2002
- journal article
- case report
- Published by Wiley in Muscle & Nerve
- Vol. 26 (6), 845-849
- https://doi.org/10.1002/mus.10246
Abstract
We describe a 27‐year‐old woman who showed the clinical triad of Fisher syndrome (ophthalmoplegia, ataxia, and areflexia), a disturbance of consciousness, facial diplegia, and hemisensory loss. Her serum was positive for anti‐GQ1b immunoglobulin G (IgG) antibody. The electroencephalographic findings (diffuse slow activity), median somatosensory evoked potential (absent cortical N20 with normal cervical N13), and blink reflex studies (absent R2) suggested central dysfunction, whereas results of facial nerve conduction studies (low amplitudes of compound muscle action potentials), F‐wave and H‐reflex studies (absent F‐waves and soleus H‐reflexes), and brainstem auditory evoked potentials (prolongation of wave I latency) suggested peripheral abnormalities. This case supports the hypothesized continuity between Fisher syndrome and Bickerstaff brainstem encephalitis. These two conditions may represent a single autoimmune disease mediated by anti‐GQ1b antibody, usually involving the peripheral and occasionally the central nervous systems. © 2002 Wiley Periodicals, Inc. Muscle Nerve 26: 000‐000, 2002Keywords
This publication has 33 references indexed in Scilit:
- NOSOLOGICAL ENTITIES?: Bickerstaff's encephalitis and the Miller Fisher syndromeJournal of Neurology, Neurosurgery & Psychiatry, 2001
- Guillain-Barre, Fisher, and Bickerstaff syndromes: nature versus well established ideasJournal of Neurology, Neurosurgery & Psychiatry, 2000
- Ataxic form of Guillain-Barre syndrome associated with anti-GD1b IgG antibodyJournal of Neurology, Neurosurgery & Psychiatry, 2000
- Efficacy of Early Plasmapheresis in Bickerstaff's Encephalitis.Internal Medicine, 1998
- Acute motor axonal neuropathy: A frequent cause of acute flaccid paralysis in ChinaAnnals of Neurology, 1993
- Miller Fisher syndrome is associated with serum antibodies to GQ1b ganglioside.Journal of Neurology, Neurosurgery & Psychiatry, 1993
- Brainstem encephalitis and the Miller Fisher syndrome.Journal of Neurology, Neurosurgery & Psychiatry, 1993
- AAEM minimonograph #13: H reflexes and F waves: Physiology and clinical indicationsMuscle & Nerve, 1992
- The nosological position of the ophthalmoplegia, ataxia and areflexia syndrome: “The spectrum hypothesis”Acta Neurologica Scandinavica, 1987
- Topographical differences in the vascular permeability of the peripheral nervous systemActa Neuropathologica, 1968