Frequency-Selective Coding of Translation and Tilt in Macaque Cerebellar Nodulus and Uvula
Open Access
- 1 October 2008
- journal article
- research article
- Published by Society for Neuroscience in Journal of Neuroscience
- Vol. 28 (40), 9997-10009
- https://doi.org/10.1523/jneurosci.2232-08.2008
Abstract
Spatial orientation depends critically on the brain's ability to segregate linear acceleration signals arising from otolith afferents into estimates of self-motion and orientation relative to gravity. In the absence of visual information, this ability is known to deteriorate at low frequencies. The cerebellar nodulus/uvula (NU) has been shown to participate in this computation, although its exact role remains unclear. Here, we show that NU simple spike (SS) responses also exhibit a frequency dependent selectivity to self-motion (translation) and spatial orientation (tilt). At 0.5 Hz, Purkinje cells encode three-dimensional translation and only weakly modulate during pitch and roll tilt (0.4 ± 0.05 spikes/s/°/s). But this ability to selectively signal translation over tilt is compromised at lower frequencies, such that at 0.05 Hz tilt response gains average 2.0 ± 0.3 spikes/s/°/s. We show that such frequency-dependent properties are attributable to an incomplete cancellation of otolith-driven SS responses during tilt by a canal-driven signal coding angular position with a sensitivity of 3.9 ± 0.3 spikes/s/°. This incomplete cancellation is brought about because otolith-driven SS responses are also partially integrated, thus encoding combinations of linear velocity and acceleration. These results are consistent with the notion that NU SS modulation represents an internal neural representation of similar frequency dependencies seen in behavior.Keywords
This publication has 78 references indexed in Scilit:
- Vestibular System: The Many Facets of a Multimodal SenseAnnual Review of Neuroscience, 2008
- Roll Tilt Psychophysics in Rhesus Monkeys During Vestibular and Visual StimulationJournal of Neurophysiology, 2008
- Responses of Monkey Vestibular-Only Neurons to Translation and Angular RotationJournal of Neurophysiology, 2006
- Sensory vestibular contributions to constructing internal models of self-motionJournal of Neural Engineering, 2005
- Transneuronal pathways to the vestibulocerebellumJournal of Comparative Neurology, 1996
- Linear Acceleration Perception: Frequency Dependence of the Hilltop IllusionActa Oto-Laryngologica, 1995
- Differential mossy fiber projections to the dorsal and ventral uvula in the catJournal of Comparative Neurology, 1989
- Topographical organization of olivocerebellar and corticonuclear connections in the rat—An WGA‐HRP study: I. Lobules IX, X, and the flocculusJournal of Comparative Neurology, 1987
- The parasagittal zonation within the olivocerebellar projection. II. Climbing fiber distribution in the intermediate and hemispheric parts of cat cerebellumJournal of Comparative Neurology, 1979
- The Effect of Semicircular Canal Stimulation During Tilting on the Subsequent Perception of the Visual VerticalActa Oto-Laryngologica, 1970