The developmental pathway for CD103+CD8+ tissue-resident memory T cells of skin
Top Cited Papers
- 27 October 2013
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Immunology
- Vol. 14 (12), 1294-1301
- https://doi.org/10.1038/ni.2744
Abstract
Tissue-resident memory T cells (TRM cells) provide superior protection against infection in extralymphoid tissues. Here we found that CD103(+)CD8(+) TRM cells developed in the skin from epithelium-infiltrating precursor cells that lacked expression of the effector-cell marker KLRG1. A combination of entry into the epithelium plus local signaling by interleukin 15 (IL-15) and transforming growth factor-beta (TGF-beta) was required for the formation of these long-lived memory cells. Notably, differentiation into TRM cells resulted in the progressive acquisition of a unique transcriptional profile that differed from that of circulating memory cells and other types of T cells that permanently reside in skin epithelium. We provide a comprehensive molecular framework for the local differentiation of a distinct peripheral population of memory cells that forms a first-line immunological defense system in barrier tissues.Keywords
This publication has 53 references indexed in Scilit:
- A vaccine strategy that protects against genital herpes by establishing local memory T cellsNature, 2012
- Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunityNature, 2012
- Memory T cells as an occupying forceEuropean Journal of Immunology, 2011
- Memory T cells persisting within the brain after local infection show functional adaptations to their tissue of residenceProceedings of the National Academy of Sciences, 2010
- Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virusNature Immunology, 2009
- Heterogeneity and Cell-Fate Decisions in Effector and Memory CD8+ T Cell Differentiation during Viral InfectionImmunity, 2007
- CD69 acts downstream of interferon-α/β to inhibit S1P1 and lymphocyte egress from lymphoid organsNature, 2006
- Lineage relationship and protective immunity of memory CD8 T cell subsetsNature Immunology, 2003
- Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodMethods, 2001
- Two subsets of memory T lymphocytes with distinct homing potentials and effector functionsNature, 1999