DcR3 and survivin are highly expressed in colorectal carcinoma and closely correlated to its clinicopathologic parameters

Abstract

To investigate the expression of death decoy receptor 3 (DcR3) and survivin in colorectal carcinoma. Tumor and normal tissues were taken from a total of 100 colorectal carcinoma patients during surgery, and the expression of DcR3 and survivin was examined by immunohistochemistry, Western blotting, and reverse transcription-polymerase chain reaction (RT-PCR) analyses. RT-PCR showed that the expression levels of DcR3 mRNA (0.846±0.242, PPPPPPP<0.01) to the differentiation of colorectal carcinoma cells, lymph node metastasis, and pathological stage were observed. The expression of DcR3 and survivin was found to be positively correlated to clinicopathologic parameters of colorectal carcinoma. The overexpressed DcR3 and survivin in colorectal cancer may contribute to the development of the cancer. The monitoring of these two proteins may be useful for the diagnosis, differentiation, metastasis, and determination of stages of colorectal carcinoma.