Spontaneous Mutation Rates at Five Coat-Color Loci in Mice

Abstract

Examination of 1.5 million mice yielded natural mutation rates estimnated from 5.2 million gene reproductions at five specific coat-color loci. The average rates were 11.1 x 10^-6 for forward mutations and 2.7 x 10^-6 for reverse mutations. Differences between the frequencies of mutations at the individual loci were evident.