Changes in the perception of inspiratory resistive loads during partial curarization.
- 1 December 1980
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 309 (1), 93-100
- https://doi.org/10.1113/jphysiol.1980.sp013496
Abstract
The ability of normal [human] subjects to estimate the magnitude of resistive loads and to detect resistive loads was determined using standard psychophysical techniques. The experiments were repeated during maintained partial neuromuscular blockade with D-tubocurarine. During curarization the ability to detect the presence of a small inspiratory resistive load was not significantly impaired. This is consistent with the view that changes in the usual breath-by-breath relation between pressure and flow mediate detection. The size of resistive loads was over-estimated during partial curarization. Subjects thus placed more reliance on sensing the increased motor command required during curarization than on alternative peripheral signals related to pressure, flow or resistance. The exponent for the power function relating the perceived magnitude of a resistive load to its actual size was reduced during partial neuromuscular blockade. Apparently detection of resistive loads depends upon sensing apparent information arising from an unexpected pressure-flow disturbance, but estimation of the size of an added load depends, in part, on sensing the outgoing motor command.This publication has 22 references indexed in Scilit:
- MUSCLE AFFERENTS AND KINAESTHESIABritish Medical Bulletin, 1977
- SENSATIONS OF HEAVINESSBrain, 1977
- Servo action in the human thumb.The Journal of Physiology, 1976
- Human Muscle Spindle Discharge during Isometric Voluntary Contractions. Amplitude Relations between Spindle Frequency and TorqueActa Physiologica Scandinavica, 1974
- Estimation of weights and tensions and apparent involvement of a “sense of effort”Experimental Neurology, 1974
- The Sensation Produced by Threshold Resistive Loads to BreathingEuropean Journal of Clinical Investigation, 1972
- Muscle spindle response at the onset of isometric voluntary contractions in man. Time difference between fusimotor and skeletomotor effectsThe Journal of Physiology, 1971
- Contribution of somatic receptors in the chest wall to detection of added inspiratory airway resistance.1967
- The role of vagal and glossopharyngeal afferent nerves in respiratory sensation, control of breathing and arterial pressure regulation in conscious man.1966
- Perception of added airflow resistance in humansRespiration Physiology, 1966