Isolation of New Protein Phosphatase Inhibitors from Two Cyanobacteria Species, Planktothrix spp.
- 1 August 2001
- journal article
- review article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 64 (8), 1052-1055
- https://doi.org/10.1021/np0005356
Abstract
Two new protein phosphatase inhibitors, oscillamide B (1) and C (2), were isolated from the cyanobacteria Planktothrix (Oscillatoria) agardhii and P. rubescens. The structures of the inhibitors were elucidated by analysis of HRFABMS, 1D and 2D NMR spectra, and chemical degradation. These inhibitors are ureido-containing cyclic peptides and inhibited serine/threonine protein phosphatases PP1 and PP2A. The inhibitory activities were closely related to the Arg and N-Me-Hty residues in the peptides.Keywords
This publication has 10 references indexed in Scilit:
- Protein phosphatase 2A inhibitors, phoslactomycins. Effects on the cytoskeleton in NIH/3T3 cells.The Journal of Biochemistry, 1999
- Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25ACell, 1998
- Three dehydrobutyrine-containing microcystins from NostocPhytochemistry, 1998
- Two new (E)-2-amino-2-butenoic acid (Dhb)-containing microcystins isolated from Oscillatoria agardhiiTetrahedron, 1998
- Nostocyclin, a novel 3-amino-6-hydroxy-2-piperidone-containing cyclic depsipeptide from the cyanobacterium Nostoc sp.Tetrahedron Letters, 1996
- Cyclic peptides and depsipeptides from cyanobacteria: A reviewJournal of Industrial Microbiology & Biotechnology, 1996
- Oscillapeptin G, a Tyrosinase Inhibitor from Toxic Oscillatoria agardhiiJournal of Natural Products, 1996
- Expression cloning of a human dual-specificity phosphatase.Proceedings of the National Academy of Sciences, 1992
- Inhibition of protein phosphatases by microcystis and nodularin associated with hepatotoxicityZeitschrift für Krebsforschung und Klinische Onkologie, 1990
- THE STRUCTURE AND REGULATION OF PROTEIN PHOSPHATASESAnnual Review of Biochemistry, 1989