Restraint Stress
- 1 January 2000
- journal article
- research article
- Published by Wolters Kluwer Health in Hypertension
- Vol. 35 (1), 126-129
- https://doi.org/10.1161/01.hyp.35.1.126
Abstract
With the use of a restraint stress paradigm, both normotensive Wistar-Kyoto (WKY ) rats and spontaneously hypertensive rats (SHR) underwent acute (1-hour restraint in a Perspex tube), chronic (1-hour restraint for 10 consecutive days), or no-restraint (control) stress. Rats experiencing chronic restraint were previously implanted with telemetric probes to measure heart rate and blood pressure. Basal (prestress session) cardiovascular variables did not change during the course of the study (SHR: mean arterial pressure 129+/-1 mm Hg, heart rate 288+/-4 bpm; WKY rats: mean arterial pressure 103+/-1 mm Hg, heart rate 285+/-3 bpm). Restraint caused tachycardia and pressor responses in the WKY rats and SHR, but these effects were greater in the hypertensive strain. The duration of restraint-induced tachycardia did not change in the WKY rats between acute and chronic stress; however, a graded reduction in the duration of restraint-induced tachycardia occurred in the SHR, decreasing to WKY rat levels by day 7 of the 10-day regimen. These data indicate that although the WKY rats can effectively "cope" within a single period of restraint, the coping mechanism is apparently impaired in the SHR compared with the WKY rats. A reduced capacity to cope with processive stressors may thus have an affect on cardiovascular regulation and represent an additional risk factor in hypertension.Keywords
This publication has 11 references indexed in Scilit:
- Expression of preprogalanin mRNA following acute and chronic restraint stress in brains of normotensive and hypertensive ratsMolecular Brain Research, 1999
- Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stressNeuroscience, 1998
- The central adaptation syndrome: Psychosocial stress as a trigger for adaptive modifications of brain structure and brain functionProgress in Neurobiology, 1996
- Regional changes in c-fos expression in the basal forebrain and brainstem during adaptation to repeated stress: Correlations with cardiovascular, hypothermic and endocrine responsesNeuroscience, 1995
- Functional organization of central pathways regulating the cardiovascular systemPhysiological Reviews, 1994
- The habituation of brainstem catecholaminergic groups to chronically daily restraint stress is stress specific like that of the hypothalamo-pituitary-adrenal axisBrain Research, 1994
- Differential regional hemodynamic changes produced by L-glutamate stimulation of the locus coeruleusBrain Research, 1993
- CRF receptor regulation and sensitization of ACTH responses to acute ether stress during chronic intermittent immobilization stressBrain Research, 1990
- Age-dependent effects of isolation housing on the self-administration of ethanol in laboratory ratsAlcohol, 1990
- Plasma corticosterone levels during repeated presentation of two intensities of restraint stress: Chronic stress and habituationPhysiology & Behavior, 1988