Entry of Herpes Simplex Virus Type 1 into Primary Sensory Neurons In Vitro Is Mediated by Nectin-1/HveC
Open Access
- 1 March 2003
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 77 (5), 3307-3311
- https://doi.org/10.1128/jvi.77.5.3307-3311.2003
Abstract
Primary cultures of rat and mouse sensory neurons were used to study the entry of herpes simplex virus type 1 (HSV-1). Soluble, truncated nectin-1 but not HveA prevented viral entry. Antibodies against nectin-1 also blocked infection of rat neurons. These results indicate that nectin-1 is the primary receptor for HSV-1 infection of sensory neurons.Keywords
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