T-Cell Responses to EBV
- 2 October 2015
- book chapter
- review article
- Published by Springer Science and Business Media LLC
- Vol. 391, 325-353
- https://doi.org/10.1007/978-3-319-22834-1_11
Abstract
Epstein–Barr virus (EBV) is arguably one of the most successful pathogens of humans, persistently infecting over ninety percent of the world’s population. Despite this high frequency of carriage, the virus causes apparently few adverse effects in the vast majority of infected individuals. Nevertheless, the potent growth transforming ability of EBV means the virus has the potential to cause malignancies in infected individuals. Indeed, EBV is thought to cause 1 % of human malignancies, equating to 200,000 malignancies each year. A clear factor as to why virus-induced disease is relatively infrequent in healthy infected individuals is the presence of a potent immune response to EBV, in particular, that mediated by T cells. Thus, patient groups with immunodeficiencies or whose cellular immune response is suppressed have much higher frequencies of EBV-induced disease and, in at least some cases, these diseases can be controlled by restoration of the T-cell compartment. In this chapter, we will primarily review the role the αβ subset of T cells in the control of EBV in healthy and diseased individuals.Keywords
This publication has 100 references indexed in Scilit:
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virusNature Immunology, 2009
- Children with endemic Burkitt lymphoma are deficient in EBNA1‐specific IFN‐γ T cell responsesInternational Journal of Cancer, 2009
- Patients with Epstein Barr virus‐positive lymphomas have decreased CD4+ T‐cell responses to the viral nuclear antigen 1International Journal of Cancer, 2008
- Spontaneous T cell responses to Epstein‐Barr virus‐encoded BARF1 protein and derived peptides in patients with nasopharyngeal carcinoma: Bases for improved immunotherapyInternational Journal of Cancer, 2008
- Increase in circulating Foxp3+CD4+CD25high regulatory T cells in nasopharyngeal carcinoma patientsBritish Journal of Cancer, 2007
- Chronic herpesvirus reactivation occurs in agingExperimental Gerontology, 2007
- Epstein-Barr virus (EBV)-encodedBARF1 gene is expressed in nasopharyngeal carcinoma and EBV-associated gastric carcinoma tissues in the absence of lytic gene expressionJournal of Medical Virology, 2005
- T-cell control of Epstein–Barr virus-infected B cells is lost during P. falciparum malariaNature, 1984
- A comparison of epstein‐barr virus‐specific T‐cell immunity in malaria‐endemic and ‐nonendemic regions of Papua New GuineaInternational Journal of Cancer, 1983